Table 1 Optimization of reaction conditions for screening catalyst and base
From: Coupling metal and whole-cell catalysis to synthesize chiral alcohols
| ||||||
|---|---|---|---|---|---|---|
Entry | Pd catalyst | Solvent | Base | Temperature (°C) | Time (h) | Yield (%) |
1 | Pd(OAc)2 | Toluene | Cs2CO3 | 80 | 0.5 | 12 |
2 | Pd/C | Toluene | Cs2CO3 | 80 | 0.5 | 7 |
3 | Pd(PPh3)4 | Toluene | Cs2CO3 | 80 | 0.5 | 76 |
4 | Pd(PPh3)4 | MeOH | Cs2CO3 | 80 | 0.5 | 25 |
5 | Pd(PPh3)4 | H2O | Cs2CO3 | 80 | 0.5 | 9 |
6 | Pd(PPh3)4 | 2-MeTHF | Cs2CO3 | 80 | 0.5 | 61 |
7 | Pd(PPh3)4 | Xylene | Cs2CO3 | 80 | 0.5 | 72 |
8 | Pd(PPh3)4 | Toluene | K2CO3 | 80 | 0.5 | 89 |
9 | Pd(PPh3)4 | Toluene | LiOH·H2O | 80 | 0.5 | 57 |
10 | Pd(PPh3)4 | Toluene | TEA | 80 | 0.5 | 64 |
11 | Pd(PPh3)4 | Xylene | K2CO3 | 80 | 3 | 98 |
12 | Pd(PPh3)4 | Xylene | K2CO3 | 25 | 3 | 10 |
13 | Pd(PPh3)4 | Xylene | K2CO3 | 60 | 3 | 70 |
14 | Pd(PPh3)4 | Xylene | K2CO3 | 70 | 3 | 77 |
15 | Pd(PPh3)4 | Xylene | K2CO3 | 90 | 3 | 97 |
