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Table 5 Genes involved in Zn, Cu and Co resistance in B. amyloliquefaciens strain Bam1 and B. velezensis strain FZB42

From: Genome sequencing of biocontrol strain Bacillus amyloliquefaciens Bam1 and further analysis of its heavy metal resistance mechanism

Metal

Gene

Location

Product or function

Identity of FZB42 (%)

Bam1

FZB24

Zn

zurR

2,470,670–2,471,080

2,461,096–2,461,506

Zn-specific metalloregulatory protein; Fur family transcriptional regulator; Zn uptake regulator

97.32

 

znuA

275,215–276,174

283,478–284,437

Zn transport system substrate-binding protein; Zn-uptake complex component A periplasmic

95.94

 

znuB

276,882–277,721

285,145–285,984

ABC transporter for Zn (permease); Zn uptake

96.43

 

znuC

276,229–276,924

284,492–285,187

Zn ABC transporter ATP-binding protein; Zn uptake

96.98

 

czrA

1,940,021–1,940,323

2,011,551–2,011,933

ArsR family transcriptional repressor, regulation of resistance against toxic metal cations; regulating the expression of cadA, czcD

97.69

 

cadA

3,237,502–3,239,613

3,183,406–3,185,517

Cd-translocating P-type ATPase; Cd2+/Zn2+/Co2+ efflux

93.51

 

czcD

506,576–507,511

537,946–538,876

Cation exporter (antiporter); cation efflux; resistance against Zn2+, Cu2+, Co2+, Ni2+, Cd2+

89.40

 

pfeT/zntA/zosA

1,370,249–1,372,162

1,321,623–1,323,536

Fe2+/Zn2+/Cd2+-exporting ATPase; cation efflux

91.54

Cu

ycnK

400,613–401,185

407,200–407,772

DeoR family transcription repressor; copper-responsive transcription repressor of the ycnK-ycnJ operon; regulation of copper uptake

97.73

 

ycnJ

398,952–400,580

418,065–419,693

Copper transport protein YcnJ; uptake of copper

93.99

 

csoR

3,242,556–3,242,855

3,188,475–3,188,767

Copper-sensing transcriptional repressor CsoR; control of copper homeostasis, including copper import and export

96.25

 

copZ

3,242,279–3,242,485

3,188,180–3,188,386

Copper chaperone CopZ; copper transport protein; resistance to copper;

95.17

 

copA

3,239,760–3,242,195

3,185,667–3,188,096

Copper-exporting P-type ATPase A; copper export

92.90

 

czcD

506,576–507,511

537,946–538,876

Cation exporter (antiporter); cation efflux; resistance against Zn2+, Cu2+, Co2+, Ni2+, Cd2+

89.40

Co

ecfA1/ybxA/thiW

1,319,552–1,321,189

1,270,763–1,272,400

Cobalt ABC transporter (ATP-binding protein); uptake of micronutrients

90.36

 

ecfT/ybaF

152,693–153,490

152,878–153,675

Cobalt ABC transporter (permease); uptake of micronutrients

94.36

 

citM

733,033–734,331

773,138–774,436

Mg2+/citrate complex secondary transporter; uptake of citrate and Mg2+, Co2+, Ni2+, Mn2+

94.00

 

cadA

3,237,502–3,239,613

3,183,406–3,185,517

Cd-translocating P-type ATPase; Cd2+/Zn2+/Co2+ efflux

93.51

 

czcD

506,576–507,511

537,946–538,876

Cation exporter (antiporter); cation efflux; resistance against Zn2+, Cu2+, Co2+, Ni2+, Cd2+

89.40