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Bioresources and Bioprocessing
Fig. 7 | Bioresources and Bioprocessing

Fig. 7

From: Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR–Cas9

Fig. 7

AP-3 production of mutants at the end of fermentation. L40, the parent strain. MD02, mutant with T1PKS-15 deletion. MD03, mutant with T1PKS-16 deletion. MD04, mutant with T1PKS-18 deletion. MD05, mutant with T1PKS/NRPS-5 deletion. MD06, mutant with NRPS-25 deletion, as the negative control. The fermentation experiments were performed for three times. The values are means ± SD (standard deviations) of three independent experiments. Significant differences were analyzed by one-way ANOVA, and **p < 0.01, ***p < 0.001, ****p < 0.0001

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