Table 2 Gene Ontology (GO) and KEGG pathways classification of Salinity–Alkalinity hub genes
A. Biological process | |||||
|---|---|---|---|---|---|
GO ID | Description | Salinity–alkalinity hub genes (16) | All (4696) | p-value | p-adjust |
GO:0,001,667 | Ameboidal-type cell migration | 6 (37.5%) | 160 (3.41%) | 0.000009 | 0.006336 |
GO:0,051,240 | Positive regulation of multicellular organismal process | 5 (31.25%) | 159 (3.39%) | 0.000135 | 0.032519 |
GO:0,016,477 | Cell migration | 7 (43.75%) | 392 (8.35%) | 0.000158 | 0.032519 |
GO:0,007,159 | Leukocyte cell–cell adhesion | 4 (25%) | 95 (2.02%) | 0.000237 | 0.032519 |
GO:0,030,335 | Positive regulation of cell migration | 3 (18.75%) | 41 (0.87%) | 0.000320 | 0.032519 |
GO:0,051,272 | Positive regulation of cellular component movement | 3 (18.75%) | 41 (0.87%) | 0.000320 | 0.032519 |
GO:2,000,147 | Positive regulation of cell motility | 3 (18.75%) | 41 (0.87%) | 0.000320 | 0.032519 |
GO:0,048,870 | Cell motility | 7 (43.75%) | 454 (9.67%) | 0.000397 | 0.032519 |
GO:0,051,674 | Localization of cell | 7 (43.75%) | 454 (9.67%) | 0.000397 | 0.032519 |
GO:0,071,624 | Positive regulation of granulocyte chemotaxis | 2 (12.5%) | 11 (0.23%) | 0.000588 | 0.043341 |
GO:0,040,017 | Positive regulation of locomotion | 3 (18.75%) | 53 (1.13%) | 0.000685 | 0.045921 |
B. Molecular function | |||||
|---|---|---|---|---|---|
GO ID | Description | Salinity–alkalinity hub genes (15) | All (4619) | p-value | p-adjust |
GO:0,042,287 | MHC protein binding | 2 (13.33%) | 14 (0.3%) | 0.000876 | 0.035368 |
GO:0,038,023 | Signaling receptor activity | 3 (20%) | 64 (1.39%) | 0.001025 | 0.035368 |
GO:0,004,872 | Receptor activity | 3 (20%) | 91 (1.97%) | 0.002835 | 0.048320 |
GO:0,023,026 | MHC class II protein complex binding | 1 (6.67%) | 1 (0.02%) | 0.003247 | 0.048320 |
GO:0,004,871 | Signal transducer activity | 3 (20%) | 98 (2.12%) | 0.003501 | 0.048320 |
C. Cellular component | |||||
|---|---|---|---|---|---|
GO ID | Description | Salinity–alkalinity hub genes (18) | All (4741) | p-value | p-adjust |
GO:0,005,886 | Plasma membrane | 6 (33.33%) | 462 (9.74%) | 0.005549 | 0.225734 |
GO:0,071,944 | Cell periphery | 6 (33.33%) | 488 (10.29%) | 0.007269 | 0.225734 |
GO:0,005,887 | Integral component of plasma membrane | 2 (11.11%) | 42 (0.89%) | 0.010716 | 0.225734 |
GO:0,043,235 | Receptor complex | 2 (11.11%) | 42 (0.89%) | 0.010716 | 0.225734 |
GO:0,031,226 | Intrinsic component of plasma membrane | 2 (11.11%) | 49 (1.03%) | 0.014409 | 0.225734 |
GO:0,098,797 | Plasma membrane protein complex | 2 (11.11%) | 49 (1.03%) | 0.014409 | 0.225734 |
GO:0,044,421 | Extracellular region part | 5 (27.78%) | 427 (9.01%) | 0.018489 | 0.237034 |
GO:0,005,576 | Extracellular region | 5 (27.78%) | 445 (9.39%) | 0.021790 | 0.237034 |
GO:0,016,021 | Integral component of membrane | 4 (22.22%) | 296 (6.24%) | 0.022695 | 0.237034 |
GO:0,030,176 | Integral component of endoplasmic reticulum membrane | 1 (5.56%) | 8 (0.17%) | 0.029995 | 0.281950 |
GO:0,044,459 | Plasma membrane part | 4 (22.22%) | 340 (7.17%) | 0.035620 | 0.304391 |
D. KEGG pathway enrichment | |||||
|---|---|---|---|---|---|
Pathway | Candidate genes with pathway annotation (19) | All genes with pathway annotation (3593) | p-value | q-value | Pathway ID |
Staphylococcus aureus infection | 5 (26.32%) | 59 (1.64%) | 0.000010 | 0.000824 | ko05150 |
Estrogen signaling pathway | 4 (21.05%) | 76 (2.12%) | 0.000563 | 0.023654 | ko04915 |
Complement and coagulation cascades | 3 (15.79%) | 43 (1.2%) | 0.001354 | 0.037915 | ko04610 |
Legionellosis | 3 (15.79%) | 63 (1.75%) | 0.004075 | 0.085579 | ko05134 |