A. Biological process | |||||
---|---|---|---|---|---|
GO ID | Description | Saline–alkaline up-regulated deps (18) | All (4696) | p-value | p-adjust |
GO:0,048,771 | Tissue remodeling | 3 (16.67%) | 19 (0.4%) | 0.000044 | 0.019294 |
GO:0,051,384 | Response to glucocorticoid | 3 (16.67%) | 23 (0.49%) | 0.000080 | 0.019294 |
GO:0,034,614 | Cellular response to reactive oxygen species | 3 (16.67%) | 25 (0.53%) | 0.000103 | 0.019294 |
GO:0,006,816 | Calcium ion transport | 4 (22.22%) | 85 (1.81%) | 0.000252 | 0.019294 |
GO:0,010,519 | Negative regulation of phospholipase activity | 2 (11.11%) | 8 (0.17%) | 0.000383 | 0.019294 |
GO:0,032,717 | Negative regulation of interleukin-8 production | 2 (11.11%) | 8 (0.17%) | 0.000383 | 0.019294 |
GO:0,060,192 | Negative regulation of lipase activity | 2 (11.11%) | 8 (0.17%) | 0.000383 | 0.019294 |
GO:0,070,838 | Divalent metal ion transport | 4 (22.22%) | 99 (2.11%) | 0.000453 | 0.019294 |
GO:0,072,511 | Divalent inorganic cation transport | 4 (22.22%) | 99 (2.11%) | 0.000453 | 0.019294 |
GO:0,034,599 | Cellular response to oxidative stress | 3 (16.67%) | 41 (0.87%) | 0.000460 | 0.019294 |
GO:0,001,516 | Prostaglandin biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:0,031,392 | Regulation of prostaglandin biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:0,042,304 | Regulation of fatty acid biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:0,046,456 | Icosanoid biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:0,046,457 | Prostanoid biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:1,901,570 | Fatty acid derivative biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:2,001,279 | Regulation of unsaturated fatty acid biosynthetic process | 2 (11.11%) | 9 (0.19%) | 0.000492 | 0.019294 |
GO:1,901,701 | Cellular response to oxygen-containing compound | 3 (16.67%) | 48 (1.02%) | 0.000734 | 0.027216 |
GO:0,032,637 | Interleukin-8 production | 2 (11.11%) | 12 (0.26%) | 0.000895 | 0.029862 |
GO:0,032,677 | Regulation of interleukin-8 production | 2 (11.11%) | 12 (0.26%) | 0.000895 | 0.029862 |
GO:1,901,989 | Positive regulation of cell cycle phase transition | 2 (11.11%) | 13 (0.28%) | 0.001056 | 0.032011 |
GO:1,901,992 | Positive regulation of mitotic cell cycle phase transition | 2 (11.11%) | 13 (0.28%) | 0.001056 | 0.032011 |
GO:0,031,960 | Response to corticosteroid | 3 (16.67%) | 57 (1.21%) | 0.001216 | 0.034156 |
GO:0,032,309 | Icosanoid secretion | 2 (11.11%) | 14 (0.3%) | 0.001229 | 0.034156 |
GO:0,071,715 | Icosanoid transport | 2 (11.11%) | 15 (0.32%) | 0.001415 | 0.036297 |
GO:1,901,571 | Fatty acid derivative transport | 2 (11.11%) | 15 (0.32%) | 0.001415 | 0.036297 |
GO:0,006,979 | Response to oxidative stress | 4 (22.22%) | 136 (2.9%) | 0.001501 | 0.037092 |
GO:0,006,952 | Defense response | 7 (38.89%) | 495 (10.54%) | 0.001562 | 0.037216 |
GO:0,090,068 | Positive regulation of cell cycle process | 2 (11.11%) | 17 (0.36%) | 0.001824 | 0.041958 |
GO:0,001,776 | Leukocyte homeostasis | 2 (11.11%) | 18 (0.38%) | 0.002048 | 0.043514 |
GO:0,046,717 | Acid secretion | 2 (11.11%) | 18 (0.38%) | 0.002048 | 0.043514 |
GO:0,046,942 | Carboxylic acid transport | 3 (16.67%) | 69 (1.47%) | 0.002115 | 0.043514 |
GO:0,015,849 | Organic acid transport | 3 (16.67%) | 70 (1.49%) | 0.002205 | 0.043514 |
GO:0,006,636 | Unsaturated fatty acid biosynthetic process | 2 (11.11%) | 19 (0.4%) | 0.002283 | 0.043514 |
GO:0,045,931 | Positive regulation of mitotic cell cycle | 2 (11.11%) | 19 (0.4%) | 0.002283 | 0.043514 |
GO:0,006,693 | Prostaglandin metabolic process | 2 (11.11%) | 20 (0.43%) | 0.002531 | 0.045632 |
GO:0,006,956 | Complement activation | 2 (11.11%) | 20 (0.43%) | 0.002531 | 0.045632 |
GO:0,044,092 | Negative regulation of molecular function | 4 (22.22%) | 159 (3.39%) | 0.002671 | 0.046881 |
B. Molecular function | |||||
---|---|---|---|---|---|
GO ID | Description | Saline–alkaline up-regulated deps (18) | All (4619) | p-value | p-adjust |
GO:0,004,859 | Phospholipase inhibitor activity | 2 (11.11%) | 9 (0.19%) | 0.000508 | 0.043946 |
GO:0,008,094 | DNA-dependent ATPase activity | 2 (11.11%) | 12 (0.26%) | 0.000925 | 0.043946 |
GO:0,055,102 | Lipase inhibitor activity | 2 (11.11%) | 15 (0.32%) | 0.001462 | 0.046287 |
C. Cellular component | |||||
---|---|---|---|---|---|
GO ID | Description | Saline–alkaline up-regulated deps (19) | All (4741) | p-value | p-adjust |
GO:0,005,576 | Extracellular region | 8 (42.11%) | 445 (9.39%) | 0.000168 | 0.012632 |
GO:0,044,421 | Extracellular region part | 7 (36.84%) | 427 (9.01%) | 0.000884 | 0.033153 |
D. KEGG pathway enrichment | |||||
---|---|---|---|---|---|
Pathway | Candidate genes with pathway annotation (11) | All genes with pathway annotation (3593) | P-value | Q -value | Pathway ID |
Neuroactive ligand–receptor interaction | 2 (18.18%) | 13 (0.36%) | 0.000653 | 0.050910 | ko04080 |
Complement and coagulation cascades | 2 (18.18%) | 43 (1.2%) | 0.007186 | 0.247888 | ko04610 |
Herpes simplex infection | 3 (27.27%) | 152 (4.23%) | 0.009534 | 0.247888 | ko05168 |
Arginine biosynthesis | 1 (9.09%) | 16 (0.45%) | 0.047973 | 0.307125 | ko00220 |