Table 4 Homeostasis, immune response and reproductive progress-related proteins under saline–alkaline stress in G. przewalskii

ANXA1

Annexin A1-like isoform X1 [Sinocyclocheilus grahami]

GO:0,001,776//leukocyte homeostasis; GO:0,002,684//positive regulation of immune system process; GO:0,006,816//calcium ion transport; GO:0,030,217//T cell differentiation; GO:0,032,717//negative regulation of interleukin-8 production; GO:0,034,097//response to cytokine; GO:0,034,614//cellular response to reactive oxygen species; GO:0,043,627//response to estrogen; GO:0,051,384//response to glucocorticoid

Atp1a1

Na + /K + ATPase alpha subunit isoform 8 [Danio rerio]

GO:0,006,875//cellular metal ion homeostasis; GO:0,010,107//potassium ion import; GO:0,031,944//negative regulation of glucocorticoid metabolic process; GO:0,048,232//male gamete generation; GO:0,071,436//sodium ion export; GO:1,902,600//hydrogen ion transmembrane transport

Tmx2b

Thioredoxin-related transmembrane protein 2-B-like [Sinocyclocheilus anshuiensis]

GO:0,019,725//cellular homeostasis

Rbp4a

Retinol-binding protein [Clarias batrachus]

GO:0,002,639//positive regulation of immunoglobulin production; GO:0,008,406//gonad development; GO:0,030,540//female genitalia development; GO:0,048,232//male gamete generation; GO:0,048,545//response to steroid hormone; GO:0,048,598//embryonic morphogenesis

Hmox

Heme oxygenase-like [Sinocyclocheilus rhinocerous]

GO:0,000,302//response to reactive oxygen species; GO:0,001,666//response to hypoxia; GO:0,002,262//myeloid cell homeostasis; GO:0,002,719//negative regulation of cytokine production involved in immune response; GO:0,002,887//negative regulation of myeloid leukocyte mediated immunity; GO:0,043,122//regulation of I-kappaB kinase/NF-kappaB signaling; GO:0,046,916//cellular transition metal ion homeostasis; GO:0,055,114//oxidation–reduction process

Atp1a3

Sodium/potassium-transporting ATPase subunit alpha-3 isoform X2 [Sinocyclocheilus grahami]

GO:0,006,875//cellular metal ion homeostasis; GO:0,010,107//potassium ion import; GO:0,015,988//energy coupled proton transmembrane transport, against electrochemical gradient; GO:0,031,944//negative regulation of glucocorticoid metabolic process; GO:0,071,436//sodium ion export

Atnb233

Sodium/potassium-transporting ATPase subunit beta-233-like [Sinocyclocheilus grahami]

GO:0,002,376//immune system process; GO:0,006,875//cellular metal ion homeostasis; GO:0,007,599//hemostasis; GO:0,010,107//potassium ion import; GO:0,032,596//protein transport into membrane raft; GO:0,071,436//sodium ion export; GO:1,901,021//positive regulation of calcium ion transmembrane transporter activity; GO:1,901,381//positive regulation of potassium ion transmembrane transport; GO:1,902,307//positive regulation of sodium ion transmembrane transport

Gpx3

Glutathione peroxidase 3-like isoform X1 [Sinocyclocheilus grahami]

GO:0,006,979//response to oxidative stress; GO:0,010,033//response to organic substance; GO:0,042,743//hydrogen peroxide metabolic process; GO:0,044,710//single-organism metabolic process; GO:0,051,260//protein homooligomerization

Tgm5

Protein-glutamine gamma-glutamyltransferase 5-like [Carassius auratus]

GO:0,032,469//endoplasmic reticulum calcium ion homeostasis; GO:0,051,560//mitochondrial calcium ion homeostasis

Pycr2

Pyrroline-5-carboxylate reductase 1, mitochondrial-like [Sinocyclocheilus grahami]

GO:0,006,561//proline biosynthetic process; GO:0,006,979//response to oxidative stress; GO:0,042,391//regulation of membrane potential; GO:0,060,548//negative regulation of cell death

F2

Complement system-related protein F2-1 [Cyprinus carpio]

GO:0,002,376//immune system process; GO:0,010,524//positive regulation of calcium ion transport into cytosol

GPX4

Glutathione peroxidase 4a isoform 2 precursor [Danio rerio]

GO:0,042,743//hydrogen peroxide metabolic process; GO:0,043,627//response to estrogen; GO:0,048,232//male gamete generation

Arg2-a

Arginase-2, mitochondrial [Sinocyclocheilus rhinocerous]

GO:0,010,038//response to metal ion; GO:0,032,769//negative regulation of monooxygenase activity; GO:0,034,614//cellular response to reactive oxygen species; GO:0,044,702//single organism reproductive process; GO:0,044,703//multi-organism reproductive process; GO:0,071,385//cellular response to glucocorticoid stimulus

Cml

Probable N-acetyltransferase camello isoform X1 [Sinocyclocheilus grahami]

GO:0,050,789//regulation of biological process; GO:0,071,704//organic substance metabolic process

LOC107985021

Flocculation protein FLO11-like [Sinocyclocheilus rhinocerous]

GO:0,045,089//positive regulation of innate immune response; GO:0,051,607//defense response to virus

NCKAP1L

Nck-associated protein 1-like [Sinocyclocheilus anshuiensis]

GO:0,002,260//lymphocyte homeostasis; GO:0,030,888//regulation of B cell proliferation; GO:0,032,846//positive regulation of homeostatic process; GO:0,033,627//cell adhesion mediated by integrin; GO:0,042,129//regulation of T cell proliferation; GO:0,043,370//regulation of CD4-positive, alpha–beta T cell differentiation; GO:0,043,376//regulation of CD8-positive, alpha–beta T cell differentiation; GO:0,045,577//regulation of B cell differentiation; GO:0,045,582//positive regulation of T cell differentiation

Cd74

H-2 class II histocompatibility antigen gamma chain-like [Carassius auratus]

GO:0,002,478//antigen processing and presentation of exogenous peptide antigen; GO:0,010,935//regulation of macrophage cytokine production; GO:0,019,724//B cell mediated immunity; GO:0,045,058//T cell selection; GO:0,071,624//positive regulation of granulocyte chemotaxis

C6

Complement component C6 [Sinocyclocheilus grahami]

GO:0,006,956//complement activation

C4B

Complement system-related protein C4b [Cyprinus carpio]

GO:0,019,724//B cell mediated immunity; GO:0,048,583//regulation of response to stimulus

Mxb

Interferon-induced GTP-binding -like protein [Labeo rohita]

GO:0,002,252//immune effector process

C3

Complement C3-like [Sinocyclocheilus rhinocerous]

GO:0,006,956//complement activation

MMP9

Mmp-9 [Schizothorax prenanti]

GO:0,002,684//positive regulation of immune system process; GO:0,043,627//response to estrogen; GO:0,044,703//multi-organism reproductive process; GO:0,070,555//response to interleukin-1

Atp1a1

Na + /K + ATPase alpha subunit isoform 8 [Danio rerio]

GO:0,048,232//male gamete generation; GO:0,048,598//embryonic morphogenesis

Rbp4a

Retinol-binding protein [Clarias batrachus]

GO:0,008,406//gonad development; GO:0,030,540//female genitalia development; GO:0,048,232//male gamete generation

GRN

Granulins-like isoform X3 [Sinocyclocheilus grahami]

GO:0,044,703//multi-organism reproductive process; GO:0,044,706//multi-multicellular organism process; GO:0,048,522//positive regulation of cellular process

MST1

Hepatocyte growth factor-like protein isoform X1 [Sinocyclocheilus rhinocerous]

GO:0,048,232//male gamete generation; GO:0,048,870//cell motility