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Bioresources and Bioprocessing
Fig. 4 | Bioresources and Bioprocessing

Fig. 4

From: Point mutation of V252 in neomycin C epimerase enlarges substrate-binding pocket and improves neomycin B accumulation in Streptomyces fradiae

Fig. 4

Catalytic mechanism of NeoN. A Tertiary structure of NeoN. B Catalytic pockets of NeoN computed by DoGSiteScorer. C Comparison of the structure of NeoN with that of NeoN–SAM complex. D RMSD of the NeoN–SAM backbone. E Surface electrostatic potential energy of NeoN–SAM–neomycin C complex. F Docking of NeoN–SAM with neomycin C

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