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Table 2 Influence of aprotic polar solvent type on the stereoselective electroreduction of 7K-LCA

From: Preparation of ursodeoxycholic acid from 7-ketone lithocholic acid by stereoselective electroreduction

No. Aprotic solvent Amount (mM) Conversion of 7K-LCAa (%) Yield of UDCAa (%)
1 48 18.8
2 DMSO 107.5 88.5 72.8
3 DMF 99.0 56.1 47.3
4 DMF 292.6 68.5 65.4
5 DMF 480.4 74.1 19.5
6 NMP 79.0 57 11.3
7 NMP 233.5 43
8 NMP 383.3 21
  1. Cathode: lead; anode: titanium-ruthenium mesh; 7K-LCA concentration: 0.04 M; supporting electrolyte concentration: 0.08 M; current density: 2.1 mA cm−2; temperature: 65 °C
  2. aConversion based on the starting material and the purity of UDCA determined by HPLC analysis