Paclitaxel (an alkaloid of diterpenoid family) is one of the most widely used anti-cancer drugs. The challenge for biosynthesis of paclitaxel lies on the insufficient precursor, such as taxadien-5α-ol. A recombinant Escherichia coli was constructed with a heterologous mevalonate pathway, a taxadiene synthase from yew, and a cytochrome P450-mediated oxygenation system for the de novo production of taxadien-5α-ol, the first product of the multi-step taxadiene oxygenation metabolism. The final production of total oxygenated taxanes was increased up to 27 mg/L in a 50-mL flask cultivation.
Construction of an Escherichia coli cell factory to synthesize taxadien-5α-ol, the key precursor of anti-cancer drug paclitaxel
Articles
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Biotransformation technology and high-value application of rapeseed meal: a review
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Antifungal activity of silver/silicon dioxide nanocomposite on the response of faba bean plants (Vicia faba L.) infected by Botrytis cinerea
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An accessory enzymatic system of cellulase for simultaneous saccharification and co-fermentation
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In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents
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Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
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Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress
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Current status of cow dung as a bioresource for sustainable development
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Agro-industrial wastes and their utilization using solid state fermentation: a review
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Leaf extract mediated green synthesis of silver nanoparticles from widely available Indian plants: synthesis, characterization, antimicrobial property and toxicity analysis
Aims and scope
Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.
BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:
- Biochemical and microbiological engineering
- Biocatalysis and biotransformation
- Biosynthesis and metabolic engineering
- Bioprocess and biosystems engineering
- Bioenergy and biorefinery
- Cell culture and biomedical engineering
- Food, agricultural and marine biotechnology
- Bioseparation and biopurification engineering
- Bioremediation and environmental biotechnology
Affiliated with
Bioresources and Bioprocessing is associated with the State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology.
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Citation impact
4.983 - 2-year Impact factor (2021)
1.601 - Source Normalized Impact per Paper (SNIP)
0.879 - SCImago Journal Rank (SJR)Speed
24 days to first decision for all manuscripts (Median)
33 days to first decision for reviewed manuscripts only (Median)Usage
808,036 downloads (2021)
58 Altmetric mentions (2021)
- ISSN: 2197-4365 (electronic)
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