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Bioproduction of Biliverdin from Heme Using Recombinant Pichia pastoris Cells

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Biliverdin, a bile pigment transformed from heme by heme oxygenase (HO), serves multiple functions in the human body, including antioxidant, anti-inflammatory, and immune response inhibitory activities. In this research, the production of biliverdin by biotransformation of exogenous heme was investigated using recombinant HO-expressing yeast cells. The heme oxygenase-1 gene (HO1) encoding an inducible plastidic isozyme from Arabidopsis thaliana, was recombined into Pichia pastoris GS115 cells with the plastid transport peptide sequence removed. Then the whole cells of GS115-HO1 were employed as catalysts to convert heme chloride (hemin) into biliverdin. It was shown that the yield of biliverdin was 132 mg/L when hemin (0.8 g/L) was added to the culture of GS115-HO1 and incubated for 4 h at 30 °C. The findings of this study have laid a good foundation for future applications of this method for the economical bioproduction of biliverdin.

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Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

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