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Improve the uronate dehydrogenase performance by semi-rational engineering

Uronate dehydrogenases (UDHs) are the key enzymes for the production of glucaric acid, one of the top value-added chemicals from biomass, but the poor thermostability and low activity limit their industrial application. Prof. Lou’s group (South China University of Technology, Guangzhou) improved the thermostability and specific activity of UDH by site-directed semi-rational design. The resultant triple mutant (A39P/H99Y/H234K) may allow industrial production of glucaric acid from glucuronic acid.

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Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

  • Biochemical and microbiological engineering
  • Biocatalysis and biotransformation
  • Biosynthesis and metabolic engineering
  • Bioprocess and biosystems engineering
  • Bioenergy and biorefinery
  • Cell culture and biomedical engineering
  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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