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A two-component signal transduction system RimA1A2 that negatively regulates oxytetracycline biosynthesis in Streptomyces rimosus M4018

New Content ItemStreptomyces rimosus has been recognized to be important in industry due to the production of antibiotic oxytetracycline (OTC). Prof. Guo and his coworkers at ECUST (China) clarified that the two component system such as RapA1A2 represses the expression of OTC synthetic pathway genes, and that rimA1-disrupted mutant shows significant increase in OTC titer when minimal medium was used, while it was not the case of rich media. It was also revealed that the rimA1-disrupted mutant is resistant against osmotic and oxidative stresses. These findings are important for further metabolic engineering towards antibiotic production in industry.

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Advanced Biomanufacturing for Sustainable Future
Deadline for submissions: 31st May 2019



Aims and scope

Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

  • Biochemical and microbiological engineering
  • Biocatalysis and biotransformation
  • Biosynthesis and metabolic engineering
  • Bioprocess and biosystems engineering
  • Bioenergy and biorefinery
  • Cell culture and biomedical engineering
  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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    • ProQuest Biological Science Database
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    • ProQuest Natural Science Collection
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