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Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

New Content Item (2)Ultraviolet (UV) rays can cause skin photoaging. In order to explore the protective effect and application potential of A. pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells, this study investigates the anti-aging and anti-inflammatory effects of A. pullulans lysate as well as the mechanism of anti-oxidative stress at the cellular and molecular levels, where the experimental results show that the A. pullulans lysate can effectively reduce the loss of extracellular matrix components, such as collagen and hyaluronic acid. It is also capable of scavenging excess ROS, thereby increasing the activity of catalase, decreasing the overexpression of intracellular matrix metalloproteinases, while decreasing the level of inflammatory factors, and reducing UV-induced apoptosis of HaCaT cells. Meanwhile, oxidative stress homeostasis is also regulated through the Nrf2/Keap1 and MAPK signaling pathways.  


Aims and scope

Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

  • Biochemical and microbiological engineering
  • Biocatalysis and biotransformation
  • Biosynthesis and metabolic engineering
  • Bioprocess and biosystems engineering
  • Bioenergy and biorefinery
  • Cell culture and biomedical engineering
  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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  • 2022 Citation Impact
    4.6 - 2-year Impact Factor
    6.1 - 5-year Impact Factor
    1.232 - SNIP (Source Normalized Impact per Paper)
    0.766 - SJR (SCImago Journal Rank)

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    6 days submission to first editorial decision for all manuscripts (Median)
    80 days submission to accept (Median)

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