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Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model

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Cervical cancer is a serious health problem in women. However, the use of clinical drug is seriously hampered by the development of drug resistance. Efficient in vitro tumor model is essential to improve the efficiency of drug screening and the accuracy of clinical application. Multicellular tumor spheroids (MTSs) can recapitulates tumor traits in vivo, thereby representing a powerful transitional model between 2D monolayer culture and xenograft. The cytotoxicity results showed the enhanced 5-fluorouracil (5-FU) resistance of HeLa carcinoma cells in 3D MTSs than 2D monolayer culture. This study formulates a rapid, scalable and reproducible in vitro model of 3D MTS for drug screening purposes, and the multi-OMICS analysis was made to better understand the key regulatory genes and regulated metabolic pathways responsible for the drug resistance mechanism.

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Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

  • Biochemical and microbiological engineering
  • Biocatalysis and biotransformation
  • Biosynthesis and metabolic engineering
  • Bioprocess and biosystems engineering
  • Bioenergy and biorefinery
  • Cell culture and biomedical engineering
  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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