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A novel strategy for efficient disaccharides synthesis from glucose by β-glucosidase

Oligosaccharides have important therapeutic applications. Prof. Xu Fang and his coworkers at Shandong University proposed a Hydropathy Index For Enzyme Activity (HIFEA) strategy for the rational design of β-glucosidases toward the enzymatic synthesis of oligosaccharides via reverse hydrolysis. The resultant variant TrCel1bI177S/I174S/W173H enhanced the total production of the disaccharides synthesized by 3.5-fold that of wild type, up to 196 g/L/g enzyme. The results demonstrate that the average hydropathy index is an important factor for the synthesis of laminaribiose, sophorose and cellobiose.

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Call for Papers

Biochemical engineering: perspectives in the golden age of bioeconomy

A special issue in memory of Prof. Daniel I. C. Wang for his excellent contributions and achievements in the field of biochemical and biological engineering.

Submission deadline: Apr. 30, 2021


Aims and scope

Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

  • Biochemical and microbiological engineering
  • Biocatalysis and biotransformation
  • Biosynthesis and metabolic engineering
  • Bioprocess and biosystems engineering
  • Bioenergy and biorefinery
  • Cell culture and biomedical engineering
  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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