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Big-data analysis for the improvement of monoclonal antibody (mAb) production


Big-data analysis is becoming more and more important. In particular, the integration of transcriptomics data with metabolic profiling (metabolomics) data and metabolic flux analysis is useful for the improvement and optimization of bioprocesses. The present research shows a novel method of multi-variate analysis (multi-way partial least square, PLS) for the chemometrics models that can identify the key metabolites (amino acids) that influence the monoclonal antibody production. Then new feeding strategies were implemented based on such data analysis for the improvement of the titer in the fed-batch cultivation. Big-data analysis is becoming more and more important. In particular, the integration of transcriptomics data with metabolic profiling (metabolomics) data and metabolic flux analysis is useful for the improvement and optimization of bioprocesses. The present research shows a novel method of multi-variate analysis (multi-way partial least square, PLS) for the chemometrics models that can identify the key metabolites (amino acids) that influence the monoclonal antibody production. Then new feeding strategies were implemented based on such data analysis for the improvement of the titer in the fed-batch cultivation.

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Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

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  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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