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Uridine Controls Antibody Quality in CHO Cell Culture

New Content ItemCharge heterogeneity is one of the most critical quality attributes of antibodies, which strongly influences their biological activity and safety. Identification of the key factors that affect the content of charge variants is of great importance for establishing a competitive culture process. In this study, prof. Wen-Song Tan, Dr. Li Fan and their co-workers at ECUST (Shanghai) first illustrated uridine’s significant impacts on the antibody’s charge heterogeneity in CHO cell cultures.

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Advanced Biomanufacturing for Sustainable Future
Deadline for submissions: 31st May 2019



Aims and scope

Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

  • Biochemical and microbiological engineering
  • Biocatalysis and biotransformation
  • Biosynthesis and metabolic engineering
  • Bioprocess and biosystems engineering
  • Bioenergy and biorefinery
  • Cell culture and biomedical engineering
  • Food, agricultural and marine biotechnology
  • Bioseparation and biopurification engineering
  • Bioremediation and environmental biotechnology

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