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Table 2 Stereoselective biotransformation of styrene derivatives
figurea

From: Asymmetric bio-epoxidation catalyzed with the styrene monooxygenase from Pseudomonas sp. LQ26

Entry Substrate Relative activity (%) ee (%)
1 Styrene (1a) 100 >99
2 R2 = Me (2a) 97 >99
3 R1 = Me (3a) 93 >99
4 R2, R3 = Me (4a) 71 >99
5 R2 = –CH=CH2 (5a) 64 96
6 R2 = Et (6a)a 51 >99
7 R3 = Et (7a)a 10 >99
8 R1 = Et (8a) 39 >99
9 R2 = n-Pr (9a)b 15 >99
10 R3 = n-Pr (10a)b 3 >99
11 R2 = i-Pr (11a) 15 >99
12 R1 = n-Pr (12a) 7 >99
  1. aAdded as a mixture with 6a:7a = 1:0.8
  2. bAdded as a mixture with 9a:10a = 1:0.7