Table 2 Stereoselective biotransformation of styrene derivatives
From: Asymmetric bio-epoxidation catalyzed with the styrene monooxygenase from Pseudomonas sp. LQ26
Entry | Substrate | Relative activity (%) | ee (%) |
|---|---|---|---|
1 | Styrene (1a) | 100 | >99 |
2 | R2 = Me (2a) | 97 | >99 |
3 | R1 = Me (3a) | 93 | >99 |
4 | R2, R3 = Me (4a) | 71 | >99 |
5 | R2 = –CH=CH2 (5a) | 64 | 96 |
6 | R2 = Et (6a)a | 51 | >99 |
7 | R3 = Et (7a)a | 10 | >99 |
8 | R1 = Et (8a) | 39 | >99 |
9 | R2 = n-Pr (9a)b | 15 | >99 |
10 | R3 = n-Pr (10a)b | 3 | >99 |
11 | R2 = i-Pr (11a) | 15 | >99 |
12 | R1 = n-Pr (12a) | 7 | >99 |