Table 3 Comparison of two methods in the production of chiral glycidol derivatives
From: Asymmetric bio-epoxidation catalyzed with the styrene monooxygenase from Pseudomonas sp. LQ26
Entry | R= | Method 1a | Method 2a | ||||
|---|---|---|---|---|---|---|---|
Yield (%)b | ee (%) | dr | Yield (%)b | ee (%) | dr | ||
1 | Ph | 50 | >99 | 98:2 | >99 | >99 | >99:1 |
2 | m-FC6H4 | 51 | >99 | 96:4 | 97 | >99 | >99:1 |
3 | p-FC6H4 | 50 | >99 | 96:4 | 98 | >99 | >99:1 |
4 | m-ClC6H4 | 42 | 97 | 89:11 | 83 | >99 | >99:1 |
5 | p-ClC6H4 | 46 | >99 | >99:1 | 84 | >99 | >99:1 |
6 | m-BrC6H4 | 28 | 92 | 87:13 | 54 | >99 | >99:1 |
7 | p-BrC6H4 | 35 | >99 | >99:1 | 64 | >99 | >99:1 |
8 | m-MeC6H4 | 48 | >99 | 98:2 | 87 | >99 | >99:1 |
9 | p-MeC6H4 | 50 | 98 | >99:1 | 86 | >99 | >99:1 |
10 | m-OMeC6H4 | 17 | >99 | 92:8 | 37 | >99 | >99:1 |
11 | p-OMeC6H4 | 17 | >99 | 98:2 | 75 | >99 | >99:1 |
12 | 2-thienyl | 58 | 98 | 62:38 | 79 | >99 | 96:4 |
13 | 3-thienyl | 40 | >99 | 92:8 | 98 | >99 | >99:1 |
14 | benzyl | 25 | >99 | 86:14 | 55 | >99 | >99:1 |