Skip to main content
Bioresources and Bioprocessing
Fig. 5 | Bioresources and Bioprocessing

Fig. 5

From: Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast

Fig. 5

Coexpression of tapA improved lovastatin production in a shake flask and bioreactor. a Comparison of lovastatin titers between strains P. p/LV_V#9 and P. p/LV_V#9-TapA. b Intracellular lovastatin concentration changes in P. p/LV_V#9 and P. p/LV_V#9-TapA. c P. p/LV_V#9 and P. p/LV_V#9-TapA were employed for fermentation in 3 L of basal salt medium broth in a 5-L bioreactor. Broth samples (2 mL) were collected at 8-h intervals and were analyzed twice to quantify cell growth and lovastatin concentration. Culture methods were the same for both strains. The fermentation experiments in bioreactors were conducted two times

Back to article page