Table 1 Proposed classification of Bacillaceae bacteriocins in class I (post-translationally modified peptides)

Lantibiotics type A

Lantibiotics of linear peptides that are modified by LanB and LanC enzymes and processed by a LanP protease (e.g. single-peptide, linear secondary structure, positively charged at neutral pH, elongated lantibiotics)

Ericin S and A (B. subtilis), Subtilin (B. subtilis ATCC 6633), Entianin (B. subtilis), Subtilomycin (B. subtilis MMA7), Ticins (B. thuringiensis BMB3201), Geobacillin I (Geobacillus thermodenitrificans NG80-2), Penisin (Paenibacillus sp. Strain A3), Elgicins (Paenibacillus elgii B69), Paenibacillin (Paenibacillus polymyxa OSY-DF)

Xin et al. (2015), Phelan et al. (2013), Teng et al. (2012), Garg et al. (2014), Huang and Yousef (2015), Baindara et al. (2015), Geiger et al. (2017), Bochmann et al. (2015), Fuchs et al. (2011)

Lantibiotics type B1

Lantibiotics of globular peptides that are modified by LanM enzymes and processed by a LanT ABC transporter with N-terminal-associated protease activity (e.g. noncharged or slightly negatively charged at neutral pH)

Mersacidin (B. amyloliquefaciens FZB42; Bacillus sp. HIL), Pseudomycoicidin (B. Pseudomycoides), Amylolysin (B. amyloliquefaciens), Geobacillin II (Geobacillus thermodenitrificans NG80-2)

Arias et al. (2013), Basi-Chipalu et al. (2015), Schmitz et al. (2006), Garg et al. (2012), Liu et al. (2013), Scholz et al. (2014), Herzner et al. (2011)

Lantibiotics type B2

Two-component lantibiotics consisting of two synergistically acting peptides that are modified by a single LanM-type enzyme

Haloduracin (B. halodurans), Lichenicidin (B. licheniformis VK21), RX7 (B. amyloliquefaciens), Formicin (B. paralicheniformis APC 1576), Cerecidins (B. cereus), Thusin (B. thuringiensis BGSC 4BT1)

Lawton et al. (2007), Xin et al. (2016), Begley et al. (2009), Collins et al. (2016), Wang et al. (Wang 2014a, b), Lim et al. (2016)

Sactibiotics

Peptides containing cysteine sulphur to α-carbon linkages mediated via post-translational modifications (e.g. one or more thioether bonds in its structure, a circular sactibiotic)

Subtilosin A (B. subtilis), Amysin (B. amyloliquefaciens), Thuricin CD (B. thuringiensis) with two peptides, Thurincin H (B. thuringiensis SF361)

Murphy et al. (2011), Rea et al. (2010), Wieckowski et al. (2015), Mathur et al. (2017), Kaewklom et al. (2013), Flühe et al. (2012)

TOMMs

It contains biosynthetic gene cluster which encodes a small precursor peptide that is post-translationally modified to contain thiazole and (methyl) oxazole heterocycles

Microcin B17 (E. coli strains carrying plasmid pMccB17), Sonorensin (B. sonorensis), Lichenicidin (B. licheniformis ATCC 14580), some thiopeptides

Liu et al. (2013), Begley et al. (2009), Chopra et al. (2014)