Table 1 Establishment of important cell lines for research and biopharmaceutical manufacturing in order of year of origin
From: Applications and analysis of hydrolysates in animal cell culture
Name | Species and tissue | Morphology | Culture in serum-free media | Year of origin |
|---|---|---|---|---|
L929 | Mouse connective tissue | Fibroblast | No | 1948; Earle et al. (1943) |
HeLa | Human cervix | Epithelial | Yes | 1951; Gey (1952) |
CHO | Chinese hamster ovary | Epithelial-like | Yes | 1957; Tjio and Puck (1958) |
Baby hamster kidney (BHK) cells | Hamster kidney cells | Fibroblast | Yes | 1961; Hernandez and Brown (2010) |
Vero | African green monkey kidney | Fibroblast | Yes | 1962; Yasumura and Kawakita (1963) |
3T3 | Mouse embryo | Fibroblast | No | 1962; Todaro and Green (1963) |
U-2 OS | Human osteosarcoma | Epithelial | No | 1964; Ponten and Saksela (1967) |
MCF 7 | Human adenocarcinoma | Epithelial | No | 1970; Soule et al. (1973) |
HT1080 | Human fibrosarcoma | Epithelial | No | 1974; Rasheed et al. (1974) |
Sp2/0 | Fused BALB/c mouse spleen cell and mouse myeloma P3X63Ag8 | Lymphoblast | Yes | 1975; KÖHler and Milstein (1975) |
Caco-2 | Human colorectal adenocarcinoma | Epithelial | No | 1977; Fogh et al. (1977) |
Jurkat | Human T cell leukemia | Lymphoblast | No | 1977; Schneider, et al. (1977) |
HEK293 | Human embryonic kidney | Epithelial | Yes | 1977; Graham et al. (1977) |
THP-1 | Human monocytic leukemia | Monocytic | Yes | 1980; Tsuchiya et al. (1980) |
NS0 | Murine myeloma | Lymphoblast | Yes | 1981; Galfrè and Milstein (1981) |
PER.C6 | Human embryonic retinal cells | Epithelial | Yes | 1999; Havenga et al. (2008) |
HKB-11 | human hybrid kidney/B cell | Epithelial | Yes | 2001; Cho et al. (2003) |
AGE1.CR | Duck embryo | Fibroblast | Yes | 2007; Jordan et al. (2009) |
CEVEC’s amniocyte production (CAP) | Primary human amniocytes | Epithelial | Yes | 2011; Wölfel et al. (2011) |