Table 6 Pharmacokinetic parameters of COS 2 and COS 3 after intragastric administration and intravenous administration (data derived from non-compartmental model, mean ± SD, n = 6)
From: Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats
Parameters | Unit | i.g. COS 2 | i.g. COS 3 | i.v. COS 2 | i.v. COS 3 | ||
|---|---|---|---|---|---|---|---|
100Â mg/kg | 500Â mg/kg | 100Â mg/kg | 500Â mg/kg | 100Â mg/kg | 100Â mg/kg | ||
AUC0-t | mg/L·h | 4.09 ± 0.68 | 16.38 ± 2.19 | 4.81 ± 0.65 | 20.01 ± 4.29 | 820.24 ± 67.60 | 1340.53 ± 130.92 |
AUC0-∞ | mg/L·h | 4.30 ± 1.08 | 16.61 ± 2.32 | 5.40 ± 0.76 | 21.44 ± 5.51 | 821.81 ± 68.03 | 1340.55 ± 130.93 |
MRT0-t | h | 4.12 ± 1.21 | 3.71 ± 0.82 | 4.14 ± 1.60 | 4.02 ± 1.47 | 0.44 ± 0.06 | 0.38 ± 0.11 |
MRT0-∞ | h | 6.49 ± 3.95 | 4.20 ± 0.94 | 6.57 ± 2.45 | 5.63 ± 3.00 | 0.46 ± 0.07 | 0.39 ± 0.11 |
t1/2z | h | 5.52 ± 6.50 | 3.95 ± 1.84 | 5.09 ± 1.83 | 5.90 ± 3.52 | 0.84 ± 0.33 | 0.58 ± 0.12 |
Tmax | h | 0.75 ± 0.00 | 0.79 ± 0.10 | 0.71 ± 0.10 | 0.92 ± 0.13 | 0.08 ± 0.00 | 0.08 ± 0.00 |
CLZ/F | L/h/kg | 24.43 ± 5.81 | 30.63 ± 4.58 | 18.82 ± 2.64 | 24.84 ± 7.41 | 0.12 ± 0.01 | 0.08 ± 0.01 |
VZ/F | L/kg | 162.32 ± 136.07 | 167.10 ± 64.50 | 134.33 ± 38.50 | 189.30 ± 78.96 | 0.15 ± 0.06 | 0.06 ± 0.02 |
Cmax | mg/L | 1.53 ± 0.34 | 5.61 ± 1.46 | 2.33 ± 0.60 | 7.88 ± 1.87 | 2137.85 ± 335.25 | 3312.24 ± 160.94 |
F0-∞ | % | 0.52 | 0.40 | 0.40 | 0.32 | N/A | N/A |