Table 8 Main pharmacokinetic parameters of COS 2 and COS 3 after intravenous administration (mean ± SD, n = 5, data from compartment model)
From: Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats
Parameters | Unit | Values (mean ± SD) | |
|---|---|---|---|
COS 2 | COS 3 | ||
t1/2α | h | 0.08 ± 0.04 | 0.16 ± 0.08 |
t1/2β | h | 0.52 ± 0.04 | 1.48 ± 0.97 |
V1 | L/kg | 0.02 ± 0.01 | 0.03 ± 0.01 |
CL | L/h/kg | 0.09 ± 0.01 | 0.06 ± 0.00 |
AUC0-t | mg/L·h | 889.00 ± 84.43 | 1386.34 ± 105.09 |
AUC0-∞ | mg/L·h | 1148.84 ± 141.98 | 1764.47 ± 93.07 |
K10 | 1/h | 4.64 ± 2.24 | 2.42 ± 1.16 |
K12 | 1/h | 5.98 ± 3.36 | 3.22 ± 4.55 |
K21 | 1/h | 2.13 ± 0.32 | 1.15 ± 1.61 |