Table 1 Rapamycin biosynthetic genes in Streptomyces hygroscopicus ATCC29253
Gene | Size (aa) | Putative function |
|---|---|---|
rapA | 8563 | Polyketide synthase (PKS) |
rapB | 10223 | Polyketide synthase (PKS) |
rapC | 6020 | Polyketide synthase (PKS) |
orfD | 387 | Unknown |
orfE | 465 | Unknown |
orfF | 453 | Transporter |
rapG | 330 | Regulation |
rapH | 872 | Regulation |
rapI | 260 | Modification |
rapJ | 386 | Modification |
rapK | 334 | Starter unit biosynthesis |
rapL | 345 | Precursor synthesis |
rapM | 317 | Encoding a methyltransferase |
rapN | 404 | Modification |
rapO | 77 | Modification |
rapP | 1541 | Nonribosomal peptide synthetase (NRPS) |
rapQ | 317 | Modification |