Characterization of pH-responsive high molecular-weight chitosan/poly (vinyl alcohol) hydrogel prepared by gamma irradiation for localizing drug release

Bioresources and Bioprocessing

Table 3 Kinetic models of CS/PVA irradiated hydrogel (50/50): drug-release rate constants, diffusion exponents, diffusion types, and regression values in diverse media

Drug loaded in CS/PVA gels (µg/mg polymer)	Releasing media	Kinetic models
		Zero-order	First-order	Hixson-Crowell	Higuchi	Korsmeyer–Peppas
		r²	r²	r²	r²	k	n	r²
11.4	pH 2.1; PBS	0.9015	0.7850	0.8355	0.9878	0.0175	0.61 ± 0.04	0.9782
11.0	pH 7.4; PBS	0.8656	0.7630	0.7968	0.9618	0.0084	0.63 ± 0.05	0.9630
11.0	pH 5.5; DI	0.9743	0.8675	0.9192	0.9818	0.0023	0.72 ± 0.01	0.9981