Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24:2783–2840
CAS
PubMed
Google Scholar
Almagro L, Carbonell-Bejerano P, Belchí-Navarro S, Bru R, Martínez-Zapater JM, Lijavetzky D, Pedreño MA (2014) Dissecting the transcriptional response to elicitors in Vitis vinifera cells. PLoS ONE 9:e109777
Article
PubMed
PubMed Central
CAS
Google Scholar
An CH, Lee KW, Lee SH, Jeong YJ, Woo SG, Chun H, Park Y-I, Kwak S-S, Kim CY (2015) Heterologous expression of IbMYB1a by different promoters exhibits different patterns of anthocyanin accumulation in tobacco. Plant Physiol Biochem 89:1–10
Article
CAS
PubMed
Google Scholar
Bavaresco L, Petegolli D, Cantù E, Fregoni M, Chiusa G, Trevisan M (1997) Elicitation and accumulation of stilbene phytoalexins in grapevine berries infected by Botrytis cinerea. Vitis 36:77–83
CAS
Google Scholar
Beekwilder J, Wolswinkel R, Jonker H, Hall R, de Vos CHR, Bovy A (2006) Production of resveratrol in recombinant microorganisms. Appl Environ Microbiol 72:5670–5672
Article
CAS
PubMed
PubMed Central
Google Scholar
Belchí-Navarro S, Almagro L, Lijavetzky D, Bru R, Pedreño MA (2012) Enhanced extracellular production of trans-resveratrol in Vitis vinifera suspension cultured cells by using cyclodextrins and methyljasmonate. Plant Cell Rep 31:81–89
Article
PubMed
CAS
Google Scholar
Belhadj A, Telef N, Saigne C, Cluzet S, Barrieu F, Hamdi S, Mérillon J-M (2008) Effect of methyl jasmonate in combination with carbohydrates on gene expression of PR proteins, stilbene and anthocyanin accumulation in grapevine cell cultures. Plant Physiol Biochem 46:493–499
Article
CAS
PubMed
Google Scholar
Bhat KPL, Pezzuto JM (2002) Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci 957:210–229
Article
CAS
PubMed
Google Scholar
Bradamante S, Barenghi L, Villa A (2004) Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev 22:169–188
Article
CAS
PubMed
Google Scholar
Bru R, Sellés S, Casado-Vela J, Belchí-Navarro S, Pedreño MA (2006) Modified cyclodextrins are chemically defined glucan inducers of defense responses in grapevine cell cultures. J Agric Food Chem 54:65–71
Article
CAS
PubMed
Google Scholar
Calderon AA, Zapata JM, Ros Barcelo A (1994) Peroxidase-mediated formation of resveratrol oxidation products during the hypersensitive-like reaction of grapevine cells to an elicitor from Trichoderma viride. Physiol Mol Plant Pathol 44:289–299
Article
CAS
Google Scholar
Chastang T, Pozzobon V, Taidi B, Courot E, Clément C, Pareau D (2018) Resveratrol production by grapevine cells in fed-batch bioreactor: experiments and modelling. Biochem Eng J 131:9–16
Article
CAS
Google Scholar
Chialva C, Muñoz C, Miccono M, Eichler E, Calderón L, Prieto H, Lijavetzky D (2018) Differential expression patterns within the grapevine stilbene synthase gene family revealed through their regulatory regions. Plant Mol Biol Rep 36:225–238
Article
CAS
Google Scholar
Delaunois B, Cordelier S, Conreux A, Clément C, Jeandet P (2009) Molecular engineering of resveratrol in plants. Plant Biotechnol J 7:2–12
Article
CAS
PubMed
Google Scholar
Donnez D, Jeandet P, Clément C, Courot E (2009) Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms. Trends Biotechnol 27:706–713
Article
CAS
PubMed
Google Scholar
Donnez D, Kim K-H, Antoine S, Conreux A, De Luca V, Jeandet P, Clément C, Courot E (2011) Bioproduction of resveratrol and viniferins by an elicited grapevine cell culture in a 2 L stirred bioreactor. Process Biochem 46:1056–1062
Article
CAS
Google Scholar
Giri CC, Zaheer M (2016) Chemical elicitors versus secondary metabolite production in vitro using plant cell, tissue and organ cultures: recent trends and a sky eye view appraisal. Plant Cell Tiss Org Cult 126:1–18
Article
CAS
Google Scholar
Goswami SK, Das DK (2009) Resveratrol and chemoprevention. Cancer Lett 284:1–6
Article
CAS
PubMed
Google Scholar
Grotewold E (2004) The challenges of moving chemicals within and out of cells: insights into the transport of plant natural products. Planta 219:906–909
Article
CAS
PubMed
Google Scholar
Homova V, Weber J, Schulze J, Alipieva K, Bley T, Georgiev M (2010) Devil’s claw hairy root culture in flasks and in a 3-L bioreactor: bioactive metabolite accumulation and flow cytometry. Z Naturforsch C 65:472–478
Article
CAS
PubMed
Google Scholar
Hussain MS, Fareed S, Ansari S, Rahman MA, Ahmad I (2012) Current approaches toward production of secondary plant metabolites. J Pharm Bioallied Sci 4:10–20
Article
PubMed
PubMed Central
CAS
Google Scholar
Jaillon O, Aury JM, Noel B, Policriti A, Clepet C, Casagrande A, Choisne N et al (2007) The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla. Nature 449:463–467
Article
CAS
PubMed
Google Scholar
Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CWW, Fong HHS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220
Article
CAS
PubMed
Google Scholar
Jeandet P, Douillet-Breuil A-C, Bessis R, Debord S, Sbaghi M, Adrian M (2002) Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism. J Agric Food Chem 50:2731–2741
Article
CAS
PubMed
Google Scholar
Jeandet P, Clément C, Tisserant L-P, Crouzet J, Courot É (2016) Use of grapevine cell cultures for the production of phytostilbenes of cosmetic interest. C R Chim 19:1062–1070
Article
CAS
Google Scholar
Jeandet P, Sobarzo-Sánchez E, Clément C, Nabavi SF, Habtemariam S, Nabavi SM, Cordelier S (2018) Engineering stilbene metabolic pathways in microbial cells. Biotechnol Adv 36:2264–2283
Article
CAS
PubMed
Google Scholar
Jeandet P, Sobarzo-Sánchez E, Silva AS, Clément C, Nabavi SF, Battino M, Rasekhian M, Belwal T, Habtemariam S, Koffas M, Nabavi SM (2020) Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives. Biotechnol Adv 39:107461
Article
CAS
PubMed
Google Scholar
Jeong YJ, An CH, Woo SG, Jeong HJ, Kim Y-M, Park S-J, Yoon BD, Kim CY (2014) Production of pinostilbene compounds by the expression of resveratrol O-methyltransferase genes in Escherichia coli. Enzyme Microb Technol 54:8–14
Article
CAS
PubMed
Google Scholar
Jeong YJ, Woo SG, An CH, Jeong HJ, Hong Y-S, Kim Y-M, Ryu YB, Rho M-C, Lee WS, Kim CY (2015) Metabolic engineering for resveratrol derivative biosynthesis in Escherichia coli. Mol Cells 38:318–326
Article
CAS
PubMed
PubMed Central
Google Scholar
Jeong YJ, An CH, Woo SG, Park JH, Lee K-W, Lee S-H, Rim Y, Jeong HJ, Ryu YB, Kim CY (2016) Enhanced production of resveratrol derivatives in tobacco plants by improving the metabolic flux of intermediates in the phenylpropanoid pathway. Plant Mol Biol 92:117–129
Article
CAS
PubMed
Google Scholar
Jeong YJ, An CH, Park S-C, Pyun JW, Lee J, Kim SW, Kim H-S, Kim H, Jeong JC, Kim CY (2018) Methyl jasmonate increases isoflavone production in soybean cell cultures by activating structural genes involved in isoflavonoid biosynthesis. J Agric Food Chem 66:4099–4105
Article
CAS
PubMed
Google Scholar
Lambert C, Lemaire J, Auger H, Guilleret A, Reynaud R, Clément C, Courot E, Taidi B (2019) Optimize, modulate, and scale-up resveratrol and resveratrol dimers bioproduction in Vitis labrusca L. cell suspension from flasks to 20 L bioreactor. Plants 8:576
Article
CAS
Google Scholar
Langcake P, Pryce RJ (1977) A new class of phytoalexins from grapevines. Experientia 33:151–152
Article
CAS
PubMed
Google Scholar
Lijavetzky D, Almagro L, Belchi-Navarro S, Martínez-Zapater JM, Bru R, Pedreño MA (2008) Synergistic effect of methyljasmonate and cyclodextrin on stilbene biosynthesis pathway gene expression and resveratrol production in Monastrell grapevine cell cultures. BMC Res Notes 1:132
Article
PubMed
PubMed Central
CAS
Google Scholar
Liu Z (2011) Diterpene glycosides as natural solubilizers. US Patent Application PCT/US2011, 0033525
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25:402–408
Article
CAS
PubMed
Google Scholar
Martinez-Esteso MJ, Sellés-Marchart S, Vera-Urbina JC, Pedreño MA, Bru-Martinez R (2009) Changes of defense proteins in the extracellular proteome of grapevine (Vitis vinifera cv. Gamay) cell cultures in response to elicitors. J Proteomics 73:331–341
Article
CAS
PubMed
Google Scholar
Martínez-Márquez A, Morante-Carriel JA, Ramírez-Estrada K, Cusidó RM, Palazon J, Bru-Martínez R (2016) Production of highly bioactive resveratrol analogues pterostilbene and piceatannol in metabolically engineered grapevine cell cultures. Plant Biotechnol J 14:1813–1825
Article
PubMed
PubMed Central
CAS
Google Scholar
Maurer M, Kühleitner M, Gasser B, Mattanovich D (2006) Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris. Microb Cell Fact 5:37
Article
PubMed
PubMed Central
CAS
Google Scholar
Morales M, Bru R, García-Carmona F, Ros Barceló A, Pedreño MA (1998) Effect of dimethyl-β-cyclodextrins on resveratrol metabolism in Gamay grapevine cell cultures before and after inoculation with shape Xylophilus ampelinus. Plant Cell Tiss Org Cult 53:179–187
Article
CAS
Google Scholar
Mustafa NR, de Winter W, van Iren F, Verpoorte R (2011) Initiation, growth and cryopreservation of plant cell suspension cultures. Nat Protoc 6:715–742
Article
CAS
PubMed
Google Scholar
Mulabagal V, Tsay H-S (2004) Plant cell cultures an alternative and efficient source for the production of biologically important secondary metabolites. J Appl Sci Eng Tech 2:29–48
Google Scholar
Murthy HN, Lee E-J, Paek K-Y (2014) Production of secondary metabolites from cell and organ cultures: strategies and approaches for biomass improvement and metabolite accumulation. Plant Cell Tiss Org Cult 118:1–16
Article
CAS
Google Scholar
Namdeo A (2007) Plant cell elicitation for production of secondary metabolites: a review. Pharmacogn Rev 1:69–79
CAS
Google Scholar
Nivelle L, Hubert J, Courot E, Jeandet P, Aziz A, Nuzillard J-M, Renault J-H, Clément C, Martiny L, Delmas D, Tarpin M (2017) Anti-cancer activity of resveratrol and derivatives produced by grapevine cell suspensions in a 14 L stirred bioreactor. Molecules 22:474
Article
PubMed Central
CAS
Google Scholar
Pan Q-H, Wang L, Li J-M (2009) Amounts and subcellular localization of stilbene synthase in response of grape berries to UV irradiation. Plant Sci 176:360–366
Article
CAS
Google Scholar
Pezet R, Perret C, Jean-Denis JB, Tabacchi R, Gindro K, Viret O (2003) δ-Viniferin, a resveratrol dehydrodimer: one of the major stilbenes synthesized by stressed grapevine leaves. J Agric Food Chem 51:5488–5492
Article
CAS
PubMed
Google Scholar
Sako M, Hosokawa H, Ito T, Iinuma M (2004) Regioselective oxidative coupling of 4-hydroxystilbenes: synthesis of resveratrol and ε-viniferin (E)-dehydrodimers. J Org Chem 69:2598–2600
Article
CAS
PubMed
Google Scholar
Shen T, Wang X-N, Lou H-X (2009) Natural stilbenes: an overview. Nat Prod Rep 26:916–935
Article
CAS
PubMed
Google Scholar
Shin S-Y, Han NS, Park Y-C, Kim M-D, Seo J-H (2011) Production of resveratrol from p-coumaric acid in recombinant Saccharomyces cerevisiae expressing 4-coumarate:coenzyme A ligase and stilbene synthase genes. Enzyme Microb Technol 48:48–53
Article
CAS
PubMed
Google Scholar
Sotheeswaran S, Pasupathy V (1993) Distribution of resveratrol oligomers in plants. Phytochemistry 32:1083–1092
Article
CAS
Google Scholar
Tassoni A, Fornalè S, Franceschetti M, Musiani F, Michael AJ, Perry B, Bagni N (2005) Jasmonates and Na-orthovanadate promote resveratrol production in Vitis vinifera cv. Barbera cell cultures. New Phytol 166:895–905
Article
CAS
PubMed
Google Scholar
Uchiyama H, Tozuka Y, Nishikawa M, Takeuchi H (2012) Nanocomposite formation between alpha-glucosyl stevia and surfactant improves the dissolution profile of poorly water-soluble drug. Int J Pharm 428:183–186
Article
CAS
PubMed
Google Scholar
Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16:296–300
Article
CAS
PubMed
Google Scholar
Vannozzi A, Dry IB, Fasoli M, Zenoni S, Lucchin M (2012) Genome-wide analysis of the grapevine stilbene synthase multigenic family: genomic organization and expression profiles upon biotic and abiotic stresses. BMC Plant Biol 12:130
Article
CAS
PubMed
PubMed Central
Google Scholar
Vezzulli S, Civardi S, Ferrari F, Bavaresco L (2007) Methyl jasmonate treatment as a trigger of resveratrol synthesis in cultivated grapevine. Am J Enology Vitic 58:530–533
CAS
Google Scholar
Vitrac X, Bornet A, Vanderlinde R, Valls J, Richard T, Delaunay JC, Mérillon JM, Teissédre PL (2005) Determination of stilbenes (ε-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, ε-viniferin) in Brazilian wines. J Agric Food Chem 53:5664–5669
Article
CAS
PubMed
Google Scholar
Wan Z-L, Wang J-M, Wang L-Y, Yang X-Q, Yuan Y (2013) Enhanced physical and oxidative stabilities of soy protein-based emulsions by incorporation of a water-soluble stevioside–resveratrol complex. J Agric Food Chem 61:4433–4440
Article
CAS
PubMed
Google Scholar
Wang Y, Yu O (2012) Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells. J Biotechnol 157:258–260
Article
CAS
PubMed
Google Scholar
Wu J, Liu P, Fan Y, Bao H, Du G, Zhou J, Chen J (2013) Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from L-tyrosine. J Biotechnol 167:404–411
Article
CAS
PubMed
Google Scholar
Xue Y-Q, Di J-M, Luo Y, Cheng K-J, Wei X, Shi Z (2014) Resveratrol oligomers for the prevention and treatment of cancers. Oxid Med Cell Longev 2014:9
Article
CAS
Google Scholar
Yazaki K (2005) Transporters of secondary metabolites. Curr Opin Plant Biol 8:301–307
Article
CAS
PubMed
Google Scholar
Yu CKY, Lam CNW, Springob K, Schmidt J, Chu IK, Lo C (2006) Constitutive accumulation of cis -piceid in transgenic Arabidopsis overexpressing a sorghum stilbene synthase gene. Plant Cell Physiol 47:1017–1021
Article
CAS
PubMed
Google Scholar
Zamboni A, Vrhovsek U, Kassemeyer H-H, Mattivi F, Velasco R (2006) Elicitor-induced resveratrol production in cell cultures of different grape genotypes (Vitis spp.). Vitis 45:63–68
CAS
Google Scholar
Zhang F, Koh GY, Jeansonne DP, Hollingsworth J, Russo PS, Vicente G, Stout RW, Liu Z (2011) A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity. J Pharm Sci 100:2778–2789
Article
CAS
PubMed
Google Scholar
Zhao J, Davis LC, Verpoorte R (2005) Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv 23:283–333
Article
CAS
PubMed
Google Scholar