Carbon Monoxide Dehydrogenases (CODH)：Current Status and Potential Applications
Anthropogenic carbon dioxide (CO2) levels are rising to alarming concentrations in earth’s atmosphere, causing adverse effects and global climate changes. In this review by Dr. Mirjam Perner from GEOMAR Helmholtz Centre for Ocean Research (Kiel, Germany) focus on the enzymatic conversion of CO2 to carbon monoxide (CO), and briefly discuss the different currently known natural autotrophic CO2 fixation pathways, focusing on the reversible reaction of CO2, two electrons and protons to CO and water, catalyzed by carbon monoxide dehydrogenases (CODHs). They then move on to classify the different type of CODHs, the catalyzed reactions involved and the coupled metabolisms. Finally, the review discusses the applications of CODH enzymes in photochemical and electrochemical cells to harness CO2 from the environment transforming it into commodity chemicals.